Inactivation of calcium current in bull-frog atrial myocytes.
نویسندگان
چکیده
منابع مشابه
Inactivation, reactivation and pacing dependence of calcium current in frog cardiocytes: correlation with current density.
1. Ca2+ currents were measured in single cells isolated from frog ventricle using the whole-cell patch clamp technique and a perfused pipette. K+ currents were blocked with intracellular (120 mM) and extracellular (20 mM) Cs+. 2. A single type of Ca2+ current (ICa) was found in these cells. The current activated at voltages positive to -30 mV, exhibited a symmetrical current-voltage relationshi...
متن کاملSlow inactivation of L-type calcium current distorts the measurement of L- and T-type calcium current in Purkinje myocytes
We have examined slow inactivation of L-type calcium current in canine Purkinje myocytes with the whole cell patch clamp technique. Slow inactivation is voltage dependent. It is negligible at -50 mV but can inactivate more than half of available iCaL at -10 mV. There are two major consequences of this slow inactivation. First, standard protocols for the measurement of T-type current can dramati...
متن کاملSlow Inactivation of L-Type Calcium Current Distorts the Measurement of L- and T-Type Calcium Current in Purkinje Myocytes
We have examined slow inactivation of L-type calcium current in canine Purkinje myocytes with the whole cell patch clamp technique. Slow inactivation is voltage dependent. It is negligible at -50 mV but can inactivate more than half of available icaL at 1 0 inV. There are two major consequences of this slow inactivation. First, standard protocols for the measurement of T-type current can dramat...
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BACKGROUND Atrial fibrillation is characterized by progressive atrial structural and electrical changes (atrial remodeling) that favor arrhythmia recurrence and maintenance. Reduction of L-type Ca(2+) current (I(Ca,L)) density is a hallmark of the electrical remodeling. Alterations in atrial microRNAs could contribute to the protein changes underlying atrial fibrillation-induced atrial electric...
متن کاملVoltage dependent fast calcium current in cultured skeletal myocytes of the frog Rana temporaria.
Voltage dependent calcium currents in cultured frog embryonic skeletal myocytes at stages of development ranging from 2 to 9 days were studied using the whole-cell patch clamp technique at 19-21 degrees C. Membrane currents were recorded in the presence of 2 mmol/l Ca2+ (outside), and 60 mmol/l CsCl and 50 mmol/l TEACl (inside). In the absence of sodium current two components of inward current ...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1988
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1988.sp017250